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Use of Pharmacokinetic Modeling to Design Studies for Pathway-Specific Exposure Model Evaluation

Validating an exposure pathway model is difficult because the biomarker, which is often used to evaluate the model prediction, is an integrated measure for exposures from all the exposure routes and pathways. The purpose of this article is to demonstrate a method to use pharmacokinetic (PK) modeling...

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Detalles Bibliográficos
Autores principales: Hu, Ye, Akland, Gerry G., Pellizzari, Edo D., Berry, Maurice R., Melnyk, Lisa Jo
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Science 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253662/
https://www.ncbi.nlm.nih.gov/pubmed/15579416
http://dx.doi.org/10.1289/ehp.6367