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A highly sensitive selection method for directed evolution of homing endonucleases

Homing endonucleases are enzymes that catalyze DNA sequence specific double-strand breaks and can significantly stimulate homologous recombination at these breaks. These enzymes have great potential for applications such as gene correction in gene therapy or gene alteration in systems biology and me...

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Detalles Bibliográficos
Autores principales: Chen, Zhilei, Zhao, Huimin
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253837/
https://www.ncbi.nlm.nih.gov/pubmed/16214805
http://dx.doi.org/10.1093/nar/gni148