Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

Checkpoints maintain order and fidelity in the cell cycle by blocking late-occurring events when earlier events are improperly executed. Here we describe evidence for the participation of Chk1 in an intra-S phase checkpoint in mammalian cells. We show that both Chk1 and Chk2 are phosphorylated and a...

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Detalles Bibliográficos
Autores principales: Feijoo, Carmen, Hall-Jackson, Clare, Wu, Rong, Jenkins, David, Leitch, Jane, Gilbert, David M., Smythe, Carl
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1255922/
https://www.ncbi.nlm.nih.gov/pubmed/11535615
http://dx.doi.org/10.1083/jcb.200104099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1255922/
https://www.ncbi.nlm.nih.gov/pubmed/11535615
http://dx.doi.org/10.1083/jcb.200104099

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