Stable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity

When purified under rigorous conditions, some murine anti-double-stranded-DNA (anti-dsDNA) antibodies actually bind chromatin rather than dsDNA. This suggests that they may actually be antinucleosome antibodies that only appear to bind dsDNA when they are incompletely dissociated from nucleosomes. E...

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Detalles Bibliográficos
Autores principales: Mason, Lesley J, Lambrianides, Anastasia, Haley, Joanna D, Manson, Jessica J, Latchman, David S, Isenberg, David A, Rahman, Anisur
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257422/
https://www.ncbi.nlm.nih.gov/pubmed/16207338
http://dx.doi.org/10.1186/ar1768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257422/
https://www.ncbi.nlm.nih.gov/pubmed/16207338
http://dx.doi.org/10.1186/ar1768

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