Developmental Exposure of Rats to Chlorpyrifos Leads to Behavioral Alterations in Adulthood, Involving Serotonergic Mechanisms and Resembling Animal Models of Depression

Developmental exposure to chlorpyrifos (CPF) causes persistent changes in serotonergic (5HT) systems. We administered 1 mg/kg/day CPF to rats on postnatal days 1–4, a regimen below the threshold for systemic toxicity. When tested in adulthood, CPF-exposed animals showed abnormalities in behavioral t...

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Detalles Bibliográficos
Autores principales: Aldridge, Justin E., Levin, Edward D., Seidler, Frederic J., Slotkin, Theodore A.
Formato: Texto
Lenguaje:English
Publicado: National Institue of Environmental Health Sciences 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257542/
https://www.ncbi.nlm.nih.gov/pubmed/15866758
http://dx.doi.org/10.1289/ehp.7867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257542/
https://www.ncbi.nlm.nih.gov/pubmed/15866758
http://dx.doi.org/10.1289/ehp.7867

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