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Improvement in protein functional site prediction by distinguishing structural and functional constraints on protein family evolution using computational design
The prediction of functional sites in newly solved protein structures is a challenge for computational structural biology. Most methods for approaching this problem use evolutionary conservation as the primary indicator of the location of functional sites. However, sequence conservation reflects not...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1258172/ https://www.ncbi.nlm.nih.gov/pubmed/16224101 http://dx.doi.org/10.1093/nar/gki894 |