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Improvement in protein functional site prediction by distinguishing structural and functional constraints on protein family evolution using computational design

The prediction of functional sites in newly solved protein structures is a challenge for computational structural biology. Most methods for approaching this problem use evolutionary conservation as the primary indicator of the location of functional sites. However, sequence conservation reflects not...

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Detalles Bibliográficos
Autores principales: Cheng, Gong, Qian, Bin, Samudrala, Ram, Baker, David
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1258172/
https://www.ncbi.nlm.nih.gov/pubmed/16224101
http://dx.doi.org/10.1093/nar/gki894