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Improvement in protein functional site prediction by distinguishing structural and functional constraints on protein family evolution using computational design
The prediction of functional sites in newly solved protein structures is a challenge for computational structural biology. Most methods for approaching this problem use evolutionary conservation as the primary indicator of the location of functional sites. However, sequence conservation reflects not...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1258172/ https://www.ncbi.nlm.nih.gov/pubmed/16224101 http://dx.doi.org/10.1093/nar/gki894 |