Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domain

The key enzyme in coronavirus polyprotein processing is the viral main proteinase, M(pro), a protein with extremely low sequence similarity to other viral and cellular proteinases. Here, the crystal structure of the 33.1 kDa transmissible gastroenteritis (corona)virus M(pro) is reported. The structu...

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Detalles Bibliográficos
Autores principales: Anand, Kanchan, Palm, Gottfried J., Mesters, Jeroen R., Siddell, Stuart G., Ziebuhr, John, Hilgenfeld, Rolf
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC126080/
https://www.ncbi.nlm.nih.gov/pubmed/12093723
http://dx.doi.org/10.1093/emboj/cdf327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC126080/
https://www.ncbi.nlm.nih.gov/pubmed/12093723
http://dx.doi.org/10.1093/emboj/cdf327

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