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Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses
T-lymphocyte activation displays a remarkable combination of speed, sensitivity, and discrimination in response to peptide–major histocompatibility complex (pMHC) ligand engagement of clonally distributed antigen receptors (T cell receptors or TCRs). Even a few foreign pMHCs on the surface of an ant...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262625/ https://www.ncbi.nlm.nih.gov/pubmed/16231973 http://dx.doi.org/10.1371/journal.pbio.0030356 |