Mutations affecting cleavage at the p10-capsid protease cleavage site block Rous sarcoma virus replication

A series of amino acid substitutions (M239F, M239G, P240F, V241G) were placed in the p10-CA protease cleavage site (VVAM*PVVI) to change the rate of cleavage of the junction. The effects of these substitutions on p10-CA cleavage by RSV PR were confirmed by measuring the kinetics of cleavage of model...

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Detalles Bibliográficos
Autores principales: Vana, Marcy L, Chen, Aiping, Boross, Peter, Weber, Irene, Colman, Dalbinder, Barklis, Eric, Leis, Jonathan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262776/
https://www.ncbi.nlm.nih.gov/pubmed/16188035
http://dx.doi.org/10.1186/1742-4690-2-58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262776/
https://www.ncbi.nlm.nih.gov/pubmed/16188035
http://dx.doi.org/10.1186/1742-4690-2-58

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