HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors

RNA and DNA aptamers specific for HIV-1 reverse transcriptase (RT) can inhibit reverse transcription in vitro. RNA aptamers have been shown to potently block HIV-1 replication in culture. We previously reported mutants of HIV-1 RT with substitutions N255D or N265D that display resistance to the DNA...

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Detalles Bibliográficos
Autores principales: Fisher, Timothy S, Joshi, Pheroze, Prasad, Vinayaka R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266348/
https://www.ncbi.nlm.nih.gov/pubmed/16207371
http://dx.doi.org/10.1186/1742-6405-2-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266348/
https://www.ncbi.nlm.nih.gov/pubmed/16207371
http://dx.doi.org/10.1186/1742-6405-2-8

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