Paclitaxel Modulates TGFβ Signaling in Scleroderma Skin Grafts in Immunodeficient Mice

BACKGROUND: Systemic sclerosis (SSc) is characterized by excessive fibrosis and obliterative vascular lesions. Abnormal TGFβ activation is implicated in the pathogenesis of SSc. Aberrant TGFβ/Smad signaling can be controlled by stabilization of microtubules with paclitaxel. METHODS AND FINDINGS: SSc...

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Detalles Bibliográficos
Autores principales: Liu, Xialin, Zhu, Shoukang, Wang, Tao, Hummers, Laura, Wigley, Fredrick M, Goldschmidt-Clermont, Pascal J, Dong, Chunming
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1274282/
https://www.ncbi.nlm.nih.gov/pubmed/16250671
http://dx.doi.org/10.1371/journal.pmed.0020354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1274282/
https://www.ncbi.nlm.nih.gov/pubmed/16250671
http://dx.doi.org/10.1371/journal.pmed.0020354

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