TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations; relation to age at diagnosis and survival

BACKGROUND: Ovarian carcinomas from 30 BRCA1 germ-line carriers of two distinct high penetrant founder mutations, 20 carrying the 1675delA and 10 the 1135insA, and 100 sporadic cases were characterized for somatic mutations in the TP53 gene. We analyzed differences in relation to BRCA1 germline stat...

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Detalles Bibliográficos
Autores principales: Kringen, Pedro, Wang, Yun, Dumeaux, Vanessa, Nesland, Jahn M, Kristensen, Gunnar, Borresen-Dale, Anne-Lise, Dorum, Anne
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276789/
https://www.ncbi.nlm.nih.gov/pubmed/16229746
http://dx.doi.org/10.1186/1471-2407-5-134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276789/
https://www.ncbi.nlm.nih.gov/pubmed/16229746
http://dx.doi.org/10.1186/1471-2407-5-134

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