Invariant amino acids essential for decoding function of polypeptide release factor eRF1

In eukaryotic ribosome, the N domain of polypeptide release factor eRF1 is involved in decoding stop signals in mRNAs. However, structure of the decoding site remains obscure. Here, we specifically altered the stop codon recognition pattern of human eRF1 by point mutagenesis of the invariant Glu55 a...

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Detalles Bibliográficos
Autores principales: Kolosov, Petr, Frolova, Ludmila, Seit-Nebi, Alim, Dubovaya, Vera, Kononenko, Artem, Oparina, Nina, Justesen, Just, Efimov, Alexandr, Kisselev, Lev
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283522/
https://www.ncbi.nlm.nih.gov/pubmed/16282590
http://dx.doi.org/10.1093/nar/gki927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283522/
https://www.ncbi.nlm.nih.gov/pubmed/16282590
http://dx.doi.org/10.1093/nar/gki927

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