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Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans
Changes in the cis-regulation of neural genes likely contributed to the evolution of our species' unique attributes, but evidence of a role for natural selection has been lacking. We found that positive natural selection altered the cis-regulation of human prodynorphin, the precursor molecule f...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283535/ https://www.ncbi.nlm.nih.gov/pubmed/16274263 http://dx.doi.org/10.1371/journal.pbio.0030387 |
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author | Rockman, Matthew V Hahn, Matthew W Soranzo, Nicole Zimprich, Fritz Goldstein, David B Wray, Gregory A |
author_facet | Rockman, Matthew V Hahn, Matthew W Soranzo, Nicole Zimprich, Fritz Goldstein, David B Wray, Gregory A |
author_sort | Rockman, Matthew V |
collection | PubMed |
description | Changes in the cis-regulation of neural genes likely contributed to the evolution of our species' unique attributes, but evidence of a role for natural selection has been lacking. We found that positive natural selection altered the cis-regulation of human prodynorphin, the precursor molecule for a suite of endogenous opioids and neuropeptides with critical roles in regulating perception, behavior, and memory. Independent lines of phylogenetic and population genetic evidence support a history of selective sweeps driving the evolution of the human prodynorphin promoter. In experimental assays of chimpanzee–human hybrid promoters, the selected sequence increases transcriptional inducibility. The evidence for a change in the response of the brain's natural opioids to inductive stimuli points to potential human-specific characteristics favored during evolution. In addition, the pattern of linked nucleotide and microsatellite variation among and within modern human populations suggests that recent selection, subsequent to the fixation of the human-specific mutations and the peopling of the globe, has favored different prodynorphin cis-regulatory alleles in different parts of the world. |
format | Text |
id | pubmed-1283535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-12835352005-11-15 Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans Rockman, Matthew V Hahn, Matthew W Soranzo, Nicole Zimprich, Fritz Goldstein, David B Wray, Gregory A PLoS Biol Research Article Changes in the cis-regulation of neural genes likely contributed to the evolution of our species' unique attributes, but evidence of a role for natural selection has been lacking. We found that positive natural selection altered the cis-regulation of human prodynorphin, the precursor molecule for a suite of endogenous opioids and neuropeptides with critical roles in regulating perception, behavior, and memory. Independent lines of phylogenetic and population genetic evidence support a history of selective sweeps driving the evolution of the human prodynorphin promoter. In experimental assays of chimpanzee–human hybrid promoters, the selected sequence increases transcriptional inducibility. The evidence for a change in the response of the brain's natural opioids to inductive stimuli points to potential human-specific characteristics favored during evolution. In addition, the pattern of linked nucleotide and microsatellite variation among and within modern human populations suggests that recent selection, subsequent to the fixation of the human-specific mutations and the peopling of the globe, has favored different prodynorphin cis-regulatory alleles in different parts of the world. Public Library of Science 2005-12 2005-11-15 /pmc/articles/PMC1283535/ /pubmed/16274263 http://dx.doi.org/10.1371/journal.pbio.0030387 Text en Copyright: © 2005 Rockman et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Rockman, Matthew V Hahn, Matthew W Soranzo, Nicole Zimprich, Fritz Goldstein, David B Wray, Gregory A Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans |
title | Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans |
title_full | Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans |
title_fullStr | Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans |
title_full_unstemmed | Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans |
title_short | Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans |
title_sort | ancient and recent positive selection transformed opioid cis-regulation in humans |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283535/ https://www.ncbi.nlm.nih.gov/pubmed/16274263 http://dx.doi.org/10.1371/journal.pbio.0030387 |
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