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Chimeric peptide nucleic acid compounds modulate splicing of the bcl-x gene in vitro and in vivo
Alternative splicing of the bcl-x gene generates two transcripts: the anti-apoptotic bcl-xL isoform and the pro-apoptotic bcl-xS isoform. The ratio between the two isoforms is a key factor in development and in cancer progression. Here, we show that a short antisense chimeric peptide nucleic acid (P...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1289079/ https://www.ncbi.nlm.nih.gov/pubmed/16299354 http://dx.doi.org/10.1093/nar/gki960 |