Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells

A small cell-permeable compound, dehydroxymethylepoxyquinomicin (DHMEQ), does not inhibit phosphorylation and degradation of IκB (inhibitor of nuclear factor-κB [NF-κB]) but selectively inhibits nuclear translocation of activated NF-κB. This study aimed to demonstrate the antiarthritic effect of thi...

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Detalles Bibliográficos
Autores principales: Wakamatsu, Kyoko, Nanki, Toshihiro, Miyasaka, Nobuyuki, Umezawa, Kazuo, Kubota, Tetsuo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297584/
https://www.ncbi.nlm.nih.gov/pubmed/16277688
http://dx.doi.org/10.1186/ar1834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297584/
https://www.ncbi.nlm.nih.gov/pubmed/16277688
http://dx.doi.org/10.1186/ar1834

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