Cargando…

Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells

A small cell-permeable compound, dehydroxymethylepoxyquinomicin (DHMEQ), does not inhibit phosphorylation and degradation of IκB (inhibitor of nuclear factor-κB [NF-κB]) but selectively inhibits nuclear translocation of activated NF-κB. This study aimed to demonstrate the antiarthritic effect of thi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wakamatsu, Kyoko, Nanki, Toshihiro, Miyasaka, Nobuyuki, Umezawa, Kazuo, Kubota, Tetsuo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297584/ https://www.ncbi.nlm.nih.gov/pubmed/16277688 http://dx.doi.org/10.1186/ar1834

Ejemplares similares

NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor
por: Kubota, Tetsuo, et al.
Publicado: (2007)

Epstein-Barr virus infection and variants of Epstein-Barr nuclear antigen-1 in synovial　tissues of rheumatoid arthritis
por: Masuoka, Shotaro, et al.
Publicado: (2018)

Inhibition of Canonical NF-κB Nuclear Localization by (−)-DHMEQ via Impairment of DNA Binding
por: Horie, Kana, et al.
Publicado: (2015)

Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis
por: Miyabe, Chie, et al.
Publicado: (2019)

Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
por: Fukuda, Shin, et al.
Publicado: (2014)

Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid–lysophosphatidic acid receptor 1 cascade
por: Miyabe, Yoshishige, et al.
Publicado: (2014)

Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8
por: Hayashida, Kenji, et al.
Publicado: (2001)

Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis
por: Nanki, Toshihiro, et al.
Publicado: (2009)

Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts
por: Komano, Yukiko, et al.
Publicado: (2006)

Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity
por: Suzuki, Fumihito, et al.
Publicado: (2012)

Disabling the Nuclear Translocalization of RelA/NF-κB by a Small Molecule Inhibits Triple-Negative Breast Cancer Growth
por: Kanzaki, Hirotaka, et al.
Publicado: (2021)

Quantitative imaging assay for NF-κB nuclear translocation in primary human macrophages
por: Noursadeghi, Mahdad, et al.
Publicado: (2008)

Oxymatrine Prevents NF-κB Nuclear Translocation And Ameliorates Acute Intestinal Inflammation
por: Guzman, Javier Rivera, et al.
Publicado: (2013)

Automated Analysis of NF-κB Nuclear Translocation Kinetics in High-Throughput Screening
por: Di, Zi, et al.
Publicado: (2012)

IRF3 inhibits nuclear translocation of NF-κB to prevent viral inflammation
por: Popli, Sonam, et al.
Publicado: (2022)

Citrullination of synovial proteins in murine models of rheumatoid arthritis
por: Vossenaar, E, et al.
Publicado: (2003)

Autonomy and robustness of translocation through the nuclear pore complex: a single-molecule study
por: Dange, Thomas, et al.
Publicado: (2008)

PTEN nuclear translocation enhances neuronal injury after hypoxia-ischemia via modulation of the nuclear factor-κB signaling pathway
por: Zhao, Jing, et al.
Publicado: (2021)

TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation
por: Zhu, Jingyan, et al.
Publicado: (2015)

Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the Apc(Min/+) model
por: Kawaguchi, Makiko, et al.
Publicado: (2016)

In Vivo Imaging of Single-Molecule Translocation Through Nuclear Pore Complexes by Pair Correlation Functions
por: Cardarelli, Francesco, et al.
Publicado: (2010)

Nuclear P38: Roles in Physiological and Pathological Processes and Regulation of Nuclear Translocation
por: Maik-Rachline, Galia, et al.
Publicado: (2020)

Nuclear translocation of beta-catenin in colorectal cancer
por: Kobayashi, M, et al.
Publicado: (2000)

Nuclear factor translocation and acute anterior uveitis
por: Wang, Jing, et al.
Publicado: (2011)

DNA damage induces nuclear translocation of parkin
por: Kao, Shyan-Yuan
Publicado: (2009)

Inhibition of p65 Nuclear Translocation by Baicalein
por: Seo, Min Bum, et al.
Publicado: (2011)

Mechanical Regulation of Nuclear Translocation in Migratory Neurons
por: Nakazawa, Naotaka, et al.
Publicado: (2020)

The Rate of NF-κB Nuclear Translocation Is Regulated by PKA and A Kinase Interacting Protein 1
por: King, Charles C., et al.
Publicado: (2011)

Blockade of NF-κB nuclear translocation results in the inhibition of the invasiveness of human gastric cancer cells
por: LI, ZHI-MIN, et al.
Publicado: (2013)

Cell shape and the microenvironment regulate nuclear translocation of NF-κB in breast epithelial and tumor cells
por: Sero, Julia E, et al.
Publicado: (2015)

ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation
por: Santarsiero, Anna, et al.
Publicado: (2021)

Prolactin blocks the expression of receptor activator of nuclear factor κB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis
por: Ledesma-Colunga, Maria G., et al.
Publicado: (2017)

Theory of nuclear molecules
por: Abe, Y
Publicado: (1994)

Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation
por: Dantas, Margarida, et al.
Publicado: (2022)

The designed NF-κB inhibitor, DHMEQ, inhibits KISS1R-mediated invasion and increases drug-sensitivity in mouse plasmacytoma SP2/0 cells
por: Lin, Yinzhi, et al.
Publicado: (2021)

Cyclophilin D Regulates the Nuclear Translocation of AIF, Cardiac Endothelial Cell Necroptosis and Murine Cardiac Transplant Injury
por: Qamar, Adnan, et al.
Publicado: (2021)

Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature
por: Gerlag, Danielle M, et al.
Publicado: (2001)

Nucleocapsid protein from porcine epidemic diarrhea virus isolates can antagonize interferon-λ production by blocking the nuclear factor-κB nuclear translocation
por: Shan, Ying, et al.
Publicado: (2018)

Identification of molecules associated with response to abatacept in patients with rheumatoid arthritis
por: Yokoyama-Kokuryo, Waka, et al.
Publicado: (2020)

Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis
por: Kaneko, Kayoko, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_iv0g88cs7jsbd7smeeh99ks215