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A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor

BACKGROUND: Prostacyclin receptor (IP) and thromboxane A2 receptor (TP) belong to rhodopsin-type G protein-coupling receptors and respectively bind to prostacyclin and thromboxane A2 derived from arachidonic acid. Recently, we have determined the extracellular loop (eLP) structures of the human TP r...

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Detalles Bibliográficos
Autores principales:	Ruan, Cheng-Huai, Wu, Jaixin, Ruan, Ke-He
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298286/ https://www.ncbi.nlm.nih.gov/pubmed/16271145 http://dx.doi.org/10.1186/1471-2091-6-23

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