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Constitutive degradation of IκBα in human T lymphocytes is mediated by calpain
BACKGROUND: Activation-induced induction of transcription factor NFκB in T lymphocytes is regulated by its inhibitor IκBα. NFκB activation has been demonstrated to occur either by phosphorylation on serine residues 32 and 36 of the inhibitor, IκBα, followed by ubiquitination and degradation of the i...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298323/ https://www.ncbi.nlm.nih.gov/pubmed/16271147 http://dx.doi.org/10.1186/1742-4933-2-15 |