Rotation of DNA around intact strand in human topoisomerase I implies distinct mechanisms for positive and negative supercoil relaxation

Topoisomerases are enzymes of quintessence to the upkeep of superhelical DNA, and are vital for replication, transcription and recombination. An atomic-resolution model for human topoisomerase I in covalent complex with DNA is simulated using molecular dynamics with external potentials that mimic to...

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Detalles Bibliográficos
Autores principales: Sari, Levent, Andricioaei, Ioan
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298917/
https://www.ncbi.nlm.nih.gov/pubmed/16314322
http://dx.doi.org/10.1093/nar/gki935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298917/
https://www.ncbi.nlm.nih.gov/pubmed/16314322
http://dx.doi.org/10.1093/nar/gki935

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