AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation

Thymidine depletion is toxic to virtually all actively growing cells. The fundamental mechanism responsible for thymidineless death remains unknown. One event thought to be critical in causing the toxicity of thymidine depletion is a sharp rise in the ratio of dUTP to dTTP and subsequent incorporati...

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Detalles Bibliográficos
Autores principales: Dornfeld, Ken, Johnson, Monika
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298931/
https://www.ncbi.nlm.nih.gov/pubmed/16314323
http://dx.doi.org/10.1093/nar/gki975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298931/
https://www.ncbi.nlm.nih.gov/pubmed/16314323
http://dx.doi.org/10.1093/nar/gki975

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