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AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation
Thymidine depletion is toxic to virtually all actively growing cells. The fundamental mechanism responsible for thymidineless death remains unknown. One event thought to be critical in causing the toxicity of thymidine depletion is a sharp rise in the ratio of dUTP to dTTP and subsequent incorporati...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298931/ https://www.ncbi.nlm.nih.gov/pubmed/16314323 http://dx.doi.org/10.1093/nar/gki975 |