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A Network of Multi-Tasking Proteins at the DNA Replication Fork Preserves Genome Stability

To elucidate the network that maintains high fidelity genome replication, we have introduced two conditional mutant alleles of DNA2, an essential DNA replication gene, into each of the approximately 4,700 viable yeast deletion mutants and determined the fitness of the double mutants. Fifty-six DNA2-...

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Detalles Bibliográficos
Autores principales: Budd, Martin E, Tong, Amy Hin Yan, Polaczek, Piotr, Peng, Xiao, Boone, Charles, Campbell, Judith L
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298934/
https://www.ncbi.nlm.nih.gov/pubmed/16327883
http://dx.doi.org/10.1371/journal.pgen.0010061