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PKQuest: capillary permeability limitation and plasma protein binding – application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics
BACKGROUND: It is generally assumed that the tissue exchange of antibiotics is flow limited (complete equilibration between the capillary and the tissue water). This assumption may not be valid if there is a large amount of plasma protein binding because the effective capillary permeability depends...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130020/ https://www.ncbi.nlm.nih.gov/pubmed/12323078 http://dx.doi.org/10.1186/1472-6904-2-7 |