Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA(2) phosphorylation and translocation

BACKGROUND: The 85-kDa cytosolic phospholipase A(2) (cPLA(2)) mediates arachidonic acid (AA) release in MDCK cells. Although calcium and mitogen-activated protein kinases regulate cPLA(2), the correlation of cPLA(2) translocation and phosphorylation with MAPK activation and AA release is unclear. RE...

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Detalles Bibliográficos
Autores principales: Evans, John H, Fergus, Daniel J, Leslie, Christina C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130032/
https://www.ncbi.nlm.nih.gov/pubmed/12370087
http://dx.doi.org/10.1186/1471-2091-3-30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130032/
https://www.ncbi.nlm.nih.gov/pubmed/12370087
http://dx.doi.org/10.1186/1471-2091-3-30

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