The polypyrimidine tract-binding protein stimulates HIF-1α IRES-mediated translation during hypoxia

When oxygen supply is restricted, protein synthesis is rapidly abrogated owing to inhibition of global translation. However, HIF-1α protein expression can persist during hypoxia, owing to an internal ribosome entry site (IRES) in the 5′-untranslated region of its mRNA. Here, we report on the molecul...

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Detalles Bibliográficos
Autores principales: Schepens, Bert, Tinton, Sandrine A., Bruynooghe, Yanik, Beyaert, Rudi, Cornelis, Sigrid
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310900/
https://www.ncbi.nlm.nih.gov/pubmed/16396835
http://dx.doi.org/10.1093/nar/gki1000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310900/
https://www.ncbi.nlm.nih.gov/pubmed/16396835
http://dx.doi.org/10.1093/nar/gki1000

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