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The polypyrimidine tract-binding protein stimulates HIF-1α IRES-mediated translation during hypoxia
When oxygen supply is restricted, protein synthesis is rapidly abrogated owing to inhibition of global translation. However, HIF-1α protein expression can persist during hypoxia, owing to an internal ribosome entry site (IRES) in the 5′-untranslated region of its mRNA. Here, we report on the molecul...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310900/ https://www.ncbi.nlm.nih.gov/pubmed/16396835 http://dx.doi.org/10.1093/nar/gki1000 |