Down-regulation of interferon regulatory factor 4 gene expression in leukemic cells due to hypermethylation of CpG motifs in the promoter region

Although the bcr-abl translocation has been shown to be the causative genetic aberration in chronic myeloid leukemia (CML), there is mounting evidence that the deregulation of other genes, such as the transcription factor interferon regulatory factor 4 (IRF-4), is also implicated in the pathogenesis...

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Detalles Bibliográficos
Autores principales: Ortmann, Christina A., Burchert, Andreas, Hölzle, Katharina, Nitsche, Andreas, Wittig, Burghardt, Neubauer, Andreas, Schmidt, Manuel
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310901/
https://www.ncbi.nlm.nih.gov/pubmed/16396836
http://dx.doi.org/10.1093/nar/gki1001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310901/
https://www.ncbi.nlm.nih.gov/pubmed/16396836
http://dx.doi.org/10.1093/nar/gki1001

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