Characterization of the interactions between the active site of a protein tyrosine kinase and a divalent metal activator

BACKGROUND: Protein tyrosine kinases are important enzymes for cell signalling and key targets for anticancer drug discovery. The catalytic mechanisms of protein tyrosine kinase-catalysed phosphorylation are not fully understood. Protein tyrosine kinase Csk requires two Mg(2+ )cations for activity:...

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Detalles Bibliográficos
Autores principales: Lin, Xiaofeng, Ayrapetov, Marina K, Sun, Gongqin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1316873/
https://www.ncbi.nlm.nih.gov/pubmed/16305747
http://dx.doi.org/10.1186/1471-2091-6-25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1316873/
https://www.ncbi.nlm.nih.gov/pubmed/16305747
http://dx.doi.org/10.1186/1471-2091-6-25

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