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Characterization of the interactions between the active site of a protein tyrosine kinase and a divalent metal activator
BACKGROUND: Protein tyrosine kinases are important enzymes for cell signalling and key targets for anticancer drug discovery. The catalytic mechanisms of protein tyrosine kinase-catalysed phosphorylation are not fully understood. Protein tyrosine kinase Csk requires two Mg(2+ )cations for activity:...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1316873/ https://www.ncbi.nlm.nih.gov/pubmed/16305747 http://dx.doi.org/10.1186/1471-2091-6-25 |