Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis

Human beta-defensin 2 (DEFB4, also known as DEFB2 or hBD-2) is a salt-sensitive antimicrobial protein that is expressed in lung epithelia. Previous work has shown that it is encoded in a cluster of beta-defensin genes at 8p23.1, which varies in copy number between 2 and 12 in different individuals....

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Autores principales: Hollox, Edward J, Davies, Jane, Griesenbach, Uta, Burgess, Juliana, Alton, Eric WFW, Armour, John AL
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1318481/
https://www.ncbi.nlm.nih.gov/pubmed/16336654
http://dx.doi.org/10.1186/1477-5751-4-9
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author Hollox, Edward J
Davies, Jane
Griesenbach, Uta
Burgess, Juliana
Alton, Eric WFW
Armour, John AL
author_facet Hollox, Edward J
Davies, Jane
Griesenbach, Uta
Burgess, Juliana
Alton, Eric WFW
Armour, John AL
author_sort Hollox, Edward J
collection PubMed
description Human beta-defensin 2 (DEFB4, also known as DEFB2 or hBD-2) is a salt-sensitive antimicrobial protein that is expressed in lung epithelia. Previous work has shown that it is encoded in a cluster of beta-defensin genes at 8p23.1, which varies in copy number between 2 and 12 in different individuals. We determined the copy number of this locus in 355 patients with cystic fibrosis (CF), and tested for correlation between beta-defensin cluster genomic copy number and lung disease associated with CF. No significant association was found.
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spelling pubmed-13184812005-12-22 Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis Hollox, Edward J Davies, Jane Griesenbach, Uta Burgess, Juliana Alton, Eric WFW Armour, John AL J Negat Results Biomed Research Human beta-defensin 2 (DEFB4, also known as DEFB2 or hBD-2) is a salt-sensitive antimicrobial protein that is expressed in lung epithelia. Previous work has shown that it is encoded in a cluster of beta-defensin genes at 8p23.1, which varies in copy number between 2 and 12 in different individuals. We determined the copy number of this locus in 355 patients with cystic fibrosis (CF), and tested for correlation between beta-defensin cluster genomic copy number and lung disease associated with CF. No significant association was found. BioMed Central 2005-12-07 /pmc/articles/PMC1318481/ /pubmed/16336654 http://dx.doi.org/10.1186/1477-5751-4-9 Text en Copyright © 2005 Hollox et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Hollox, Edward J
Davies, Jane
Griesenbach, Uta
Burgess, Juliana
Alton, Eric WFW
Armour, John AL
Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis
title Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis
title_full Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis
title_fullStr Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis
title_full_unstemmed Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis
title_short Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis
title_sort beta-defensin genomic copy number is not a modifier locus for cystic fibrosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1318481/
https://www.ncbi.nlm.nih.gov/pubmed/16336654
http://dx.doi.org/10.1186/1477-5751-4-9
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