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Computational modeling reveals molecular details of epidermal growth factor binding

BACKGROUND: The ErbB family of receptors are dysregulated in a number of cancers, and the signaling pathway of this receptor family is a critical target for several anti-cancer drugs. Therefore a detailed understanding of the mechanisms of receptor activation is critical. However, despite a plethora...

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Detalles Bibliográficos
Autores principales: Mayawala, Kapil, Vlachos, Dionisios G, Edwards, Jeremy S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1322221/
https://www.ncbi.nlm.nih.gov/pubmed/16318625
http://dx.doi.org/10.1186/1471-2121-6-41