Mg(2+) dependency of HIV-1 reverse transcription, inhibition by nucleoside analogues and resistance

Metal ions are essential for DNA polymerase and RNase H activities of HIV-1 reverse transcriptase (RT). RT studies are routinely performed at 6–8 mM Mg(2+), despite the fact that the in vivo concentration might be as low as 0.2 mM. We studied the influence of MgCl(2) and ATP, which likely binds a si...

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Detalles Bibliográficos
Autores principales: Goldschmidt, Valérie, Didierjean, Joël, Ehresmann, Bernard, Ehresmann, Chantal, Isel, Catherine, Marquet, Roland
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325016/
https://www.ncbi.nlm.nih.gov/pubmed/16394022
http://dx.doi.org/10.1093/nar/gkj411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325016/
https://www.ncbi.nlm.nih.gov/pubmed/16394022
http://dx.doi.org/10.1093/nar/gkj411

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