Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion

7,8-dihydro-8-oxoguanine (oxoG), the predominant lesion formed following oxidative damage of DNA by reactive oxygen species, is processed differently by replicative and bypass polymerases. Our kinetic primer extension studies demonstrate that the bypass polymerase Dpo4 preferentially inserts C oppos...

Descripción completa

Detalles Bibliográficos
Autores principales: Rechkoblit, Olga, Malinina, Lucy, Cheng, Yuan, Kuryavyi, Vitaly, Broyde, Suse, Geacintov, Nicholas E, Patel, Dinshaw J
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325099/
https://www.ncbi.nlm.nih.gov/pubmed/16379496
http://dx.doi.org/10.1371/journal.pbio.0040011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325099/
https://www.ncbi.nlm.nih.gov/pubmed/16379496
http://dx.doi.org/10.1371/journal.pbio.0040011

Ejemplares similares