Cargando…

Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease

BACKGROUND: Alzheimer's disease, a common dementia of the elder, is characterized by accumulation of protein amyloid deposits in the brain. Immunization to prevent this accumulation has been proposed as a therapeutic possibility, although adverse inflammatory reactions in human trials indicate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Jun, Fonseca, Maria I, Kayed, Rakez, Hernandez, Irma, Webster, Scott D, Yazan, Ozkan, Cribbs, David H, Glabe, Charles G, Tenner, Andrea J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326209/ https://www.ncbi.nlm.nih.gov/pubmed/16332263 http://dx.doi.org/10.1186/1742-2094-2-28

Ejemplares similares

A fibril-specific, conformation-dependent antibody recognizes a subset of Aβ plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain
por: Sarsoza, Floyd, et al.
Publicado: (2009)

CNI-1493 inhibits Aβ production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease
por: Bacher, Michael, et al.
Publicado: (2008)

Infectious etiology and amyloidosis in Alzheimer's disease: The puzzle continues
por: Kayed, Rakez
Publicado: (2021)

Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification
por: Kokubo, Hideko, et al.
Publicado: (2009)

Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies
por: Montalbano, Mauro, et al.
Publicado: (2022)

Prospects for strain-specific immunotherapy in Alzheimer’s disease and tauopathies
por: Bittar, Alice, et al.
Publicado: (2018)

por: Sokolov, Yuri, et al.
Publicado: (2006)

Soluble Amyloid Oligomers Increase Bilayer Conductance by Altering Dielectric Structure
por: Sokolov, Yuri, et al.
Publicado: (2006)

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
por: Rasool, Suhail, et al.
Publicado: (2012)

Tau Protein: Function and Pathology
por: Rosenmann, Hanna, et al.
Publicado: (2012)

Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits
por: Krishnan, Balaji, et al.
Publicado: (2018)

TAU-INDUCED ASTROCYTE SENESCENCE: A NOVEL MECHANISM FOR NEURONAL DYSFUNCTION IN ALZHEIMER’S DISEASE
por: Olson, Angela, et al.
Publicado: (2019)

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
por: Lasagna-Reeves, Cristian A., et al.
Publicado: (2012)

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin
por: Shin, Thuzar M, et al.
Publicado: (2008)

Immunotherapy for the treatment of Alzheimer’s disease: amyloid-β or tau, which is the right target?
por: Castillo-Carranza, Diana L, et al.
Publicado: (2013)

Alzheimers Disease: Review of Emerging Treatment Role for Intravenous Immunoglobulins
por: Kayed, Rakez, et al.
Publicado: (2011)

Post-translational Modifications of the p53 Protein and the Impact in Alzheimer’s Disease: A Review of the Literature
por: Clark, James S., et al.
Publicado: (2022)

Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer’s disease
por: Sengupta, Urmi, et al.
Publicado: (2018)

Quantification and targeting of elusive neurotoxic amyloid oligomers
por: Bhatt, Nemil, et al.
Publicado: (2022)

P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease
por: Farmer, Kathleen M., et al.
Publicado: (2020)

Formation and Propagation of Tau Oligomeric Seeds
por: Gerson, Julia E., et al.
Publicado: (2013)

Flanking regions, amyloid cores, and polymorphism: the potential interplay underlying structural diversity
por: Bhopatkar, Anukool A., et al.
Publicado: (2023)

Aβ/tau oligomer interplay at human synapses supports shifting therapeutic targets for Alzheimer’s disease
por: Marcatti, Michela, et al.
Publicado: (2022)

Advances and considerations in AD tau-targeted immunotherapy
por: Bittar, Alice, et al.
Publicado: (2019)

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons
por: Ruan, Zhi, et al.
Publicado: (2020)

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
por: Kayed, Rakez, et al.
Publicado: (2010)

Apolipoprotein A-I Mimetic Peptides Prevent Atherosclerosis Development and Reduce Plaque Inflammation in a Murine Model of Diabetes
por: Morgantini, Cecilia, et al.
Publicado: (2010)

Role of Receptors in Relation to Plaques and Tangles in Alzheimer’s Disease Pathology
por: Sharma, Kavita, et al.
Publicado: (2021)

Tau oligomers in cerebrospinal fluid in Alzheimer's disease
por: Sengupta, Urmi, et al.
Publicado: (2017)

Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer’s Disease Mouse Model
por: Pontrello, Crystal G., et al.
Publicado: (2022)

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy
por: Sengupta, Urmi, et al.
Publicado: (2016)

Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk
por: Kayed, Rakez, et al.
Publicado: (2020)

Cognitive composite score association with Alzheimer’s disease plaque and tangle pathology
por: Malek-Ahmadi, Michael, et al.
Publicado: (2018)

Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology
por: Rahman, M. Mahafuzur, et al.
Publicado: (2021)

The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration
por: Deger, Jennifer M, et al.
Publicado: (2015)

Association of Skin with the Pathogenesis and Treatment of Neurodegenerative Amyloidosis
por: Clos, Audra L., et al.
Publicado: (2012)

Plaque Assay for Murine Norovirus
por: Gonzalez-Hernandez, Mariam B., et al.
Publicado: (2012)

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model
por: Li, Tong, et al.
Publicado: (2016)

Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer’s disease and frontotemporal dementia
por: Gaikwad, Sagar, et al.
Publicado: (2021)

Transcriptional response of murine microglia in Alzheimer’s disease and inflammation
por: Shippy, Daniel C., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ja65bc7dqggu4aurn0fjv9ogs1