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High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans

Telomerase is essential to maintain telomere length in most eukaryotes. Other functions for telomerase have been proposed but molecular mechanisms remain unclear. We studied Caenorhabditis elegans with a mutation in the trt-1 telomerase reverse transcriptase gene. Mutant animals showed a progressive...

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Detalles Bibliográficos
Autores principales: Cheung, Iris, Schertzer, Michael, Rose, Ann, Lansdorp, Peter M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326242/
https://www.ncbi.nlm.nih.gov/pubmed/16407328
http://dx.doi.org/10.1093/nar/gkj417