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Amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice

BACKGROUND: Amiloride derivatives, commonly used for their diuretic and antihypertensive properties, can also cause a sustained but reversible decrease of intracellular pH (pH(i)). Using dimethyl amiloride (DMA) on normal rodent pancreatic islets, we previously demonstrated the critical influence of...

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Detalles Bibliográficos
Autores principales: Gunawardana, Subhadra C, Head, W Steven, Piston, David W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1327667/
https://www.ncbi.nlm.nih.gov/pubmed/16336655
http://dx.doi.org/10.1186/1472-6823-5-9