Polη, Polζ and Rev1 together are required for G to T transversion mutations induced by the (+)- and (−)-trans-anti-BPDE-N(2)-dG DNA adducts in yeast cells

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Benzo[a]pyrene is an important environmental mutagen and carcinogen. Its metabolism in cells yields the mutagenic, key ultimate carcinogen 7R,8S,9S,10R-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, (+)-anti-BPDE, which reacts via its 10-position with N(2)-dG in DNA to form the adduct (+)-trans-a...

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Detalles Bibliográficos
Autores principales: Zhao, Bo, Wang, Jillian, Geacintov, Nicholas E., Wang, Zhigang
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1331986/
https://www.ncbi.nlm.nih.gov/pubmed/16415180
http://dx.doi.org/10.1093/nar/gkj446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1331986/
https://www.ncbi.nlm.nih.gov/pubmed/16415180
http://dx.doi.org/10.1093/nar/gkj446

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