2′-Deoxy-2′-fluoro-β-d-arabinonucleic acid (2′F-ANA) modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing

To be effective in vivo, antisense oligonucleotides (AS ON) should be nuclease resistant, form stable ON/RNA duplexes and support ribonuclease H mediated heteroduplex cleavage, all with negligible non-specific effects on cell function. We report herein that AS ONs containing a 2′-deoxy-2′-fluoro-β-d...

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Detalles Bibliográficos
Autores principales: Kalota, A., Karabon, L., Swider, C. R., Viazovkina, E., Elzagheid, M., Damha, M. J., Gewirtz, A. M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1342038/
https://www.ncbi.nlm.nih.gov/pubmed/16421272
http://dx.doi.org/10.1093/nar/gkj455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1342038/
https://www.ncbi.nlm.nih.gov/pubmed/16421272
http://dx.doi.org/10.1093/nar/gkj455

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