Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell line

During culture, a chicken B cell line DT40 spontaneously mutates immunoglobulin (Ig) genes by gene conversion, which involves activation-induced cytidine deaminase (AID)-dependent homologous recombination of the variable (V) region gene with upstream pseudo-V genes. To explore whether this mutation...

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Detalles Bibliográficos
Autores principales: Kanayama, Naoki, Todo, Kagefumi, Takahashi, Satoko, Magari, Masaki, Ohmori, Hitoshi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1342040/
https://www.ncbi.nlm.nih.gov/pubmed/16421270
http://dx.doi.org/10.1093/nar/gnj013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1342040/
https://www.ncbi.nlm.nih.gov/pubmed/16421270
http://dx.doi.org/10.1093/nar/gnj013

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