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CaMKII tethers to L-type Ca(2+) channels, establishing a local and dedicated integrator of Ca(2+) signals for facilitation
Ca(2+)-dependent facilitation (CDF) of voltage-gated calcium current is a powerful mechanism for up-regulation of Ca(2+) influx during repeated membrane depolarization. CDF of L-type Ca(2+) channels (Ca(v)1.2) contributes to the positive force–frequency effect in the heart and is believed to involve...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1343528/ https://www.ncbi.nlm.nih.gov/pubmed/16275756 http://dx.doi.org/10.1083/jcb.200505155 |