Engineered external guide sequences are highly effective in inducing RNase P for inhibition of gene expression and replication of human cytomegalovirus

External guide sequences (EGSs), which are RNA molecules derived from natural tRNAs, bind to a target mRNA and render the mRNA susceptible to hydrolysis by RNase P, a tRNA processing enzyme. Using an in vitro selection procedure, we have previously generated EGS variants that efficiently direct huma...

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Detalles Bibliográficos
Autores principales: Yang, Yong-Hua, Li, Hongjian, Zhou, Tianhong, Kim, Kihoon, Liu, Fenyong
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1345693/
https://www.ncbi.nlm.nih.gov/pubmed/16432261
http://dx.doi.org/10.1093/nar/gkj431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1345693/
https://www.ncbi.nlm.nih.gov/pubmed/16432261
http://dx.doi.org/10.1093/nar/gkj431

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