Thorough validation of siRNA-induced cell death phenotypes defines new anti-apoptotic protein

Loss-of-function by means of RNA interference in cultured human cells enables rapid pathway dissection on a genome-scale. Improved siRNA design and key validation protocols are required to eliminate falsely identified phenotypes resulting from potential off-target consequences. Here, we demonstrate...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Weilin, Hodges, Emily, Höög, Christer
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1345702/
https://www.ncbi.nlm.nih.gov/pubmed/16432257
http://dx.doi.org/10.1093/nar/gnj015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1345702/
https://www.ncbi.nlm.nih.gov/pubmed/16432257
http://dx.doi.org/10.1093/nar/gnj015

Ejemplares similares