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Thorough validation of siRNA-induced cell death phenotypes defines new anti-apoptotic protein
Loss-of-function by means of RNA interference in cultured human cells enables rapid pathway dissection on a genome-scale. Improved siRNA design and key validation protocols are required to eliminate falsely identified phenotypes resulting from potential off-target consequences. Here, we demonstrate...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1345702/ https://www.ncbi.nlm.nih.gov/pubmed/16432257 http://dx.doi.org/10.1093/nar/gnj015 |