Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake

BACKGROUND: Several lines of evidence strongly suggest that agouti-related peptide (AGRP) plays a key role in the regulation of metabolic function but ablation of the AGRP gene has no apparent effect on metabolic function. Since specific pharmacological antagonists of AGRP do not presently exist, we...

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Detalles Bibliográficos
Autores principales: Makimura, Hideo, Mizuno, Tooru M, Mastaitis, Jason W, Agami, Reuven, Mobbs, Charles V
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC134599/
https://www.ncbi.nlm.nih.gov/pubmed/12423556
http://dx.doi.org/10.1186/1471-2202-3-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC134599/
https://www.ncbi.nlm.nih.gov/pubmed/12423556
http://dx.doi.org/10.1186/1471-2202-3-18

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