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Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake
BACKGROUND: Several lines of evidence strongly suggest that agouti-related peptide (AGRP) plays a key role in the regulation of metabolic function but ablation of the AGRP gene has no apparent effect on metabolic function. Since specific pharmacological antagonists of AGRP do not presently exist, we...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC134599/ https://www.ncbi.nlm.nih.gov/pubmed/12423556 http://dx.doi.org/10.1186/1471-2202-3-18 |