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Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity
BACKGROUND: Autosomal recessive juvenile parkinsonism (AR-JP) is caused by mutations in the parkin gene which encodes an E3 ubiquitin-protein ligase. Parkin is thought to be critical for protecting dopaminergic neurons from toxic insults by targeting misfolded or oxidatively damaged proteins for pro...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351194/ https://www.ncbi.nlm.nih.gov/pubmed/16375772 http://dx.doi.org/10.1186/1471-2202-6-71 |