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Computational Analysis and Prediction of the Binding Motif and Protein Interacting Partners of the Abl SH3 Domain

Protein-protein interactions, particularly weak and transient ones, are often mediated by peptide recognition domains, such as Src Homology 2 and 3 (SH2 and SH3) domains, which bind to specific sequence and structural motifs. It is important but challenging to determine the binding specificity of th...

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Detalles Bibliográficos
Autores principales: Hou, Tingjun, Chen, Ken, McLaughlin, William A, Lu, Benzhuo, Wang, Wei
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356089/
https://www.ncbi.nlm.nih.gov/pubmed/16446784
http://dx.doi.org/10.1371/journal.pcbi.0020001