Deletion of the Tetrahymena thermophila rDNA replication fork barrier region disrupts macronuclear rDNA excision and creates a fragile site in the micronuclear genome

During macronuclear development the Tetrahymena thermophila ribosomal RNA gene is excised from micronuclear chromosome 1 by site-specific cleavage at chromosome breakage sequence (Cbs) elements, rearranged into a ‘palindromic’ 21 kb minichromosome and extensively amplified. Gene amplification initia...

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Detalles Bibliográficos
Autores principales: Yakisich, J. S., Kapler, G. M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356531/
https://www.ncbi.nlm.nih.gov/pubmed/16449202
http://dx.doi.org/10.1093/nar/gkj466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356531/
https://www.ncbi.nlm.nih.gov/pubmed/16449202
http://dx.doi.org/10.1093/nar/gkj466

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